Papers with medical Large Language Models
Huatuo-26M, a Large-scale Chinese Medical QA Dataset (2025.findings-naacl)
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Xidong Wang, Jianquan Li, Shunian Chen, Yuxuan Zhu, Xiangbo Wu, Zhiyi Zhang, Xiaolong Xu, Junying Chen, Jie Fu, Xiang Wan, Anningzhe Gao, Benyou Wang
| Challenge: | Large Language Models are a powerful tool for medical research, but the data is a bottleneck. |
| Approach: | They propose to use the largest ever medical Question Answering dataset with 26 Million QA pairs as a fine-tuning data for training large language models. |
| Outcome: | The proposed dataset demonstrates that it can be used to train large language models and improves zero-shot performance on other datasets. |
Interactive Evaluation for Medical LLMs via Task-oriented Dialogue System (2025.coling-main)
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| Challenge: | In typical medical scenarios, doctors often ask a set of questions to gain a comprehensive understanding of patients’ conditions. |
| Approach: | They propose to use multi-turn medical dialogue evaluation to evaluate proactive communication and diagnostic capabilities of medical Large Language Models (LLMs) . |
| Outcome: | The proposed model outperforms existing models on multi-turn question-answering datasets and is therefore cost-effective. |
MAM: Modular Multi-Agent Framework for Multi-Modal Medical Diagnosis via Role-Specialized Collaboration (2025.findings-acl)
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| Challenge: | Recent advances in medical Large Language Models have demonstrated powerful reasoning and diagnostic capabilities. |
| Approach: | They propose a modular multi-agent framework for multi-modal medical diagnosis . they decompose the medical diagnostic process into specialized roles . |
| Outcome: | The framework decomposes the medical diagnostic process into specialized roles . it achieves significant performance improvements ranging from 18% to 365% compared to baseline models. |
ProMed: Shapley Information Gain Guided Reinforcement Learning for Proactive Medical LLMs (2026.acl-long)
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Hongxin Ding, Baixiang Huang, Yue Fang, Weibin Liao, Xinke Jiang, Jinyang Zhang, Yinghao Zhu, Zheng Li, Liantao Ma, Junfeng Zhao, Yasha Wang
| Challenge: | Existing medical Large Language Models (LLMs) follow a reactive paradigm, risking diagnostic errors by answering before seeking sufficient details. |
| Approach: | They propose a reinforcement learning framework that transitions LLMs toward a proactive paradigm, enabling them to ask clinically valuable questions before decision-making. |
| Outcome: | Experiments on partial-information medical benchmarks show that ProMed outperforms state-of-the-art methods by 6.29% on average and delivers a 54.45% gain over the reactive paradigm. |